Author: Apostolopoulos, Vasso; Thalhammer, Theresia; Tzakos, Andreas G.; Stojanovska, Lily
Title: Targeting Antigens to Dendritic Cell Receptors for Vaccine Development Cord-id: pkkpdpcf Document date: 2013_10_8
ID: pkkpdpcf
Snippet: Dendritic cells (DCs) are highly specialized antigen presenting cells of the immune system which play a key role in regulating immune responses. Depending on the method of antigen delivery, DCs stimulate immune responses or induce tolerance. As a consequence of the dual function of DCs, DCs are studied in the context of immunotherapy for both cancer and autoimmune diseases. In vaccine development, a major aim is to induce strong, specific T-cell responses. This is achieved by targeting antigen t
Document: Dendritic cells (DCs) are highly specialized antigen presenting cells of the immune system which play a key role in regulating immune responses. Depending on the method of antigen delivery, DCs stimulate immune responses or induce tolerance. As a consequence of the dual function of DCs, DCs are studied in the context of immunotherapy for both cancer and autoimmune diseases. In vaccine development, a major aim is to induce strong, specific T-cell responses. This is achieved by targeting antigen to cell surface molecules on DCs that efficiently channel the antigen into endocytic compartments for loading onto MHC molecules and stimulation of T-cell responses. The most attractive cell surface receptors, expressed on DCs used as targets for antigen delivery for cancer and other diseases, are discussed.
Search related documents:
Co phrase search for related documents- adaptive immune response and low density: 1
- adaptive immune response and low density lipoprotein: 1
- adaptive immune response and lymph node: 1, 2, 3, 4, 5, 6
- adaptive immune response and lymph node cell: 1, 2
- adaptive immune response and lymphocyte antigen: 1, 2
- adaptive immune response and lymphocytic choriomeningitis virus: 1
- adaptive immune response and lymphoid tissue: 1, 2
- adaptive immune response and macrophage monocyte: 1, 2, 3
- adaptive immunity and adenoviral vector: 1
- adaptive immunity and low affinity: 1
- adaptive immunity and low density: 1, 2, 3
- adaptive immunity and lymph node: 1, 2, 3, 4, 5, 6, 7, 8
- adaptive immunity and lymph node cell: 1
- adaptive immunity and lymphocyte antigen: 1, 2, 3, 4, 5
- adaptive immunity and lymphocytic choriomeningitis virus: 1, 2, 3
- adaptive immunity and lymphoid tissue: 1, 2, 3
- adaptive innate and adenoviral vector: 1
- adaptive innate and adjuvant poly: 1
- adaptive innate and low density: 1, 2
Co phrase search for related documents, hyperlinks ordered by date