Author: Rashmi Mohanty; Xinquan Liu; Jae You Kim; Xiujuan Peng; Sahil Bhandari; Jasmim Leal; Dhivya Arasappan; Dennis C. Wylie; Tony Dong; Debadyuti Ghosh
Title: Identification of peptide coatings that enhance diffusive transport of nanoparticles through the tumor microenvironment Document date: 2019_6_4
ID: e2uzk4u1_36
Snippet: [O-CH2-CH2]n-OH for PEG). Alternatively, due to molecular diversity of amino acids and their ordering in the peptide sequence, we can systematically manipulate select amino acids and determine their contribution to peptide-mediated transport through the ECM. To determine the impact of charge, hydrophobicity, and spatial order of physicochemical properties on transport through the ECM, we performed alanine mutagenesis on the selected P4. We substi.....
Document: [O-CH2-CH2]n-OH for PEG). Alternatively, due to molecular diversity of amino acids and their ordering in the peptide sequence, we can systematically manipulate select amino acids and determine their contribution to peptide-mediated transport through the ECM. To determine the impact of charge, hydrophobicity, and spatial order of physicochemical properties on transport through the ECM, we performed alanine mutagenesis on the selected P4. We substituted specific amino acids with alanine, which has an inert methyl functional side chain group that does not change the main conformation of the peptide, and thereby we removed the functional groups to create mutants with different surface physicochemical characteristics. We investigated the effect of net charge, hydrophobicity, and order of the amino acid sequence on diffusive transport through the tumor ECM using the aforementioned microchannel diffusion assay.
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