Selected article for: "antibody screen and high throughput"

Author: Muruato, Antonio E.; Fontes-Garfias, Camila R.; Ren, Ping; Garcia-Blanco, Mariano A.; Menachery, Vineet D.; Xie, Xuping; Shi, Pei-Yong
Title: A high-throughput neutralizing antibody assay for COVID-19 diagnosis and vaccine evaluation
  • Cord-id: on0w55x0
  • Document date: 2020_5_22
  • ID: on0w55x0
    Snippet: Virus neutralization remains the gold standard for determining antibody efficacy. Therefore, a high-throughput assay to measure SARS-CoV-2 neutralizing antibodies is urgently needed for COVID-19 serodiagnosis, convalescent plasma therapy, and vaccine development. Here we report on a fluorescence-based SARS-CoV-2 neutralization assay that detects SARS-CoV-2 neutralizing antibodies in COVID-19 patient specimens and yields comparable results to plaque reduction neutralizing assay, the gold standard
    Document: Virus neutralization remains the gold standard for determining antibody efficacy. Therefore, a high-throughput assay to measure SARS-CoV-2 neutralizing antibodies is urgently needed for COVID-19 serodiagnosis, convalescent plasma therapy, and vaccine development. Here we report on a fluorescence-based SARS-CoV-2 neutralization assay that detects SARS-CoV-2 neutralizing antibodies in COVID-19 patient specimens and yields comparable results to plaque reduction neutralizing assay, the gold standard of serological testing. Our approach offers a rapid platform that can be scaled to screen people for antibody protection from COVID-19, a key parameter necessary to safely reopen local communities.

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