Author: Monrad, Ida; Sahlertz, Signe Risgaard; Nielsen, Stine Sofie Frank; Pedersen, Louise Ørnskov; Petersen, Mikkel Steen; Kobel, Carl Mathias; Tarpgaard, Irene Harder; Storgaard, Merete; Mortensen, Klaus Leth; Schleimann, Mariane H; Tolstrup, Martin; Vibholm, Line K
Title: Persistent SARS-CoV-2 Infection in Immunocompromised Host Displaying Treatment Induced Viral Evolution Cord-id: op0s9eiu Document date: 2021_6_4
ID: op0s9eiu
Snippet: We report a COVID-19 case with SARS-CoV-2 persisting beyond 333 days in an immunocompromised patient with chronic lymphocytic leukemia, asymptomatically carrying infectious SARS-CoV-2 at day 197 post diagnosis. Additionally, viral sequencing indicates major changes in the spike protein over time, temporally associated with convalescent plasma treatment.
Document: We report a COVID-19 case with SARS-CoV-2 persisting beyond 333 days in an immunocompromised patient with chronic lymphocytic leukemia, asymptomatically carrying infectious SARS-CoV-2 at day 197 post diagnosis. Additionally, viral sequencing indicates major changes in the spike protein over time, temporally associated with convalescent plasma treatment.
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