Targets and strategies for vaccine development against SARS-CoV-2

Malik, Jonaid Ahmad; Mulla, Almas Hanif; Farooqi, Tahmeena; Pottoo, Faheem Hyder; Anwar, Sirajudheen; Rengasamy, Kannan R.R.

The SARS-CoV-2, previously called a novel coronavirus, that broke out in the Wuhan city of China caused a significant number of morbidity and mortality in the world. It is spreading at peak levels since the first case reported and the need for vaccines is in immense demand globally. Numerous treatment and vaccination strategies that were previously employed for other pathogens including coronaviruses are now beingbeen adopted to guide the formulation of new SARS-CoV-2 vaccines.Several vaccine targets can be utilized for the development ofthe SARS-CoV-2 vaccine. In this review, wehighlightedthe potential of various antigenic targets and other modes of formulating an effective vaccine against SARS-CoV-2. There are a varying number of challenges encountered during developing the most effective vaccines, andmeasures for tackling such challenges will assist in fast pace development of vaccines. This review will give a concise overview of various aspects of the vaccine development process against SARS-CoV-2 including 1) potential antigen targets 2) different vaccination strategies from conventional to novel platforms, 3) ongoing clinical trials, 4) varying challenges encountered during developing the most effective vaccine and the futuristicapproaches.