Author: Rashmi Mohanty; Xinquan Liu; Jae You Kim; Xiujuan Peng; Sahil Bhandari; Jasmim Leal; Dhivya Arasappan; Dennis C. Wylie; Tony Dong; Debadyuti Ghosh
Title: Identification of peptide coatings that enhance diffusive transport of nanoparticles through the tumor microenvironment Document date: 2019_6_4
ID: e2uzk4u1_50
Snippet: While we have demonstrated that P4 peptide facilitates and improves transport of phage (P4-phage) through the tumors, we wanted to translate peptides from the structural context of phage and demonstrate their ability as surface coatings to improve diffusive transport of synthetic nanoparticles through the tumor microenvironment towards improving drug delivery. Here, fluorescent nanoparticles were conjugated with our selected peptide or gold stand.....
Document: While we have demonstrated that P4 peptide facilitates and improves transport of phage (P4-phage) through the tumors, we wanted to translate peptides from the structural context of phage and demonstrate their ability as surface coatings to improve diffusive transport of synthetic nanoparticles through the tumor microenvironment towards improving drug delivery. Here, fluorescent nanoparticles were conjugated with our selected peptide or gold standard controls from literature, and their displacement in tumors was tracked and measured using particle tracking microscopy.
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