Author: Renata C Fleith; Harriet V Mears; Edward Emmott; Stephen C Graham; Daniel S Mansur; Trevor R Sweeney
Title: IFIT3 and IFIT2/3 promote IFIT1-mediated translation inhibition by enhancing binding to non-self RNA Document date: 2018_2_8
ID: j97gul0w_1
Snippet: The host innate immune response provides a first line defence against invading pathogens. Following infection, pathogen recognition receptors (PRRs) sense non-self, pathogen-associated molecular patterns (PAMPs) triggering signalling pathways that activate an immune response (reviewed in 1). Detection of viral signatures by PRRs, such as RIG I-like receptor sensing of double stranded RNA, induces production of Type I and Type III interferon (IFN).....
Document: The host innate immune response provides a first line defence against invading pathogens. Following infection, pathogen recognition receptors (PRRs) sense non-self, pathogen-associated molecular patterns (PAMPs) triggering signalling pathways that activate an immune response (reviewed in 1). Detection of viral signatures by PRRs, such as RIG I-like receptor sensing of double stranded RNA, induces production of Type I and Type III interferon (IFN). Through binding of cell surface IFN receptors and subsequent activation of the JAK-STAT pathway, IFN activates the transcription of hundreds of IFN-stimulated genes (ISGs) (2), many with known antiviral properties, priming neighbouring cells to restrict viral spread.
Search related documents:
Co phrase search for related documents- immune response and JAK STAT pathway: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29
- immune response and line defence: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
- immune response and molecular pattern: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38
- immune response and PAMPs molecular pattern: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
- immune response and pathogen associate: 1
- immune response and pathogen recognition: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71
- immune response and pathogen recognition receptor: 1, 2, 3, 4, 5, 6, 7, 8
- immune response and PRRs pathogen recognition receptor: 1, 2
- immune response and RIG prr: 1, 2, 3, 4
- immune response and subsequent activation: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
- immune response and viral signature: 1, 2, 3, 4, 5, 6
- immune response and viral spread: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71
- immune response and viral spread restrict: 1, 2, 3
- immune response innate and infection follow: 1, 2
- immune response innate and JAK STAT pathway: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- immune response innate and line defence: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- immune response innate and molecular pattern: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20
- immune response innate and PAMPs molecular pattern: 1, 2, 3, 4, 5, 6, 7
- immune response innate and pathogen recognition: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36
Co phrase search for related documents, hyperlinks ordered by date