Author: Renata C Fleith; Harriet V Mears; Edward Emmott; Stephen C Graham; Daniel S Mansur; Trevor R Sweeney
Title: IFIT3 and IFIT2/3 promote IFIT1-mediated translation inhibition by enhancing binding to non-self RNA Document date: 2018_2_8
ID: j97gul0w_1
Snippet: The host innate immune response provides a first line defence against invading pathogens. Following infection, pathogen recognition receptors (PRRs) sense non-self, pathogen-associated molecular patterns (PAMPs) triggering signalling pathways that activate an immune response (reviewed in 1). Detection of viral signatures by PRRs, such as RIG I-like receptor sensing of double stranded RNA, induces production of Type I and Type III interferon (IFN).....
Document: The host innate immune response provides a first line defence against invading pathogens. Following infection, pathogen recognition receptors (PRRs) sense non-self, pathogen-associated molecular patterns (PAMPs) triggering signalling pathways that activate an immune response (reviewed in 1). Detection of viral signatures by PRRs, such as RIG I-like receptor sensing of double stranded RNA, induces production of Type I and Type III interferon (IFN). Through binding of cell surface IFN receptors and subsequent activation of the JAK-STAT pathway, IFN activates the transcription of hundreds of IFN-stimulated genes (ISGs) (2), many with known antiviral properties, priming neighbouring cells to restrict viral spread.
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