Selected article for: "gene expression and pathway activation"
Author: Chin-Yi Chu; Xing Qiu; Matthew N. McCall; Lu Wang; Anthony Corbett; Jeanne Holden-Wiltse; Christopher Slaunwhite; Qian Wang; Christopher Anderson; Alex Grier; Steven R. Gill; Gloria S. Pryhuber; Ann R. Falsey; David J. Topham; Mary T. Caserta; Edward E. Walsh; Thomas J Mariani
Title: Insufficiency in airway interferon activation defines clinical severity to infant RSV infection
  • Document date: 2019_5_20
    • ID: bx49tbui_105
    Snippet: Type I/III interferon ligand gene expression over time (day 1-10) was assessed separately in mild and severely affected infants (c.) Shown is the estimated expression level (more red equals higher expression) for individual ligand genes at each day following the onset of clinical symptoms. These data are consistent with an early activation in type I/III interferon pathway activity in mild subjects only. Multiplex ELISA analysis of nasal washes fr.....
    Document: Type I/III interferon ligand gene expression over time (day 1-10) was assessed separately in mild and severely affected infants (c.) Shown is the estimated expression level (more red equals higher expression) for individual ligand genes at each day following the onset of clinical symptoms. These data are consistent with an early activation in type I/III interferon pathway activity in mild subjects only. Multiplex ELISA analysis of nasal washes from RSV infected infants (d.) confirms that the production of type I/III interferon ligands is increased in infants with severe clinical symptoms.

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