Selected article for: "antigenic protein and binding affinity"
Author: Miyssa I. Abdelmageed; Abdelrahman H. Abdelmoneim; Mujahed I. Mustafa; Nafisa M. Elfadol; Naseem S. Murshed; Shaza W. Shantier; Abdelrafie M. Makhawi
Title: Design of multi epitope-based peptide vaccine against E protein of human COVID-19: An immunoinformatics approach
  • Document date: 2020_2_11
    • ID: 6ojmmmuj_53
    Snippet: Choosing protein E as the antigenic site, the binding affinity to MHC molecules was then evaluated. The protein reference sequence was submitted to IEDB MHC predication tool. 21 peptides were found to bind MHC class I with different affinities (Table 1) , from which ten peptides were selected for vaccine design based on the number of alleles and world population percentage ( Table 2 ; Fig. 5 ).Analysis in IEDB MHC II binding prediction tool resul.....
    Document: Choosing protein E as the antigenic site, the binding affinity to MHC molecules was then evaluated. The protein reference sequence was submitted to IEDB MHC predication tool. 21 peptides were found to bind MHC class I with different affinities (Table 1) , from which ten peptides were selected for vaccine design based on the number of alleles and world population percentage ( Table 2 ; Fig. 5 ).Analysis in IEDB MHC II binding prediction tool resulted in prediction of 61 peptides (Table 2) , from which ten peptides were selected for vaccine design based on the number of alleles and world population percentage (Table 3 The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.02.04.934232 doi: bioRxiv preprint groove with MHC residues with least binding energy -13.2 kcal/mol, -11 kcal/mol and -11.3 kcal/mol, respectively (Fig.6C, D and E) .

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