Author: Asiedu Ebenezer
Title: Designing Effective small interfering RNA for Post-Transcriptional Silencing of Human GREM1: A Comprehensive Bioinformatics Approach Document date: 2020_1_24
ID: j99qg2a0_15
Snippet: The guidelines proposed by Ui-Tei, Reynolds and Amarzguioui were used to manually select the best siRNA candidates using a scoring method (Table 1 ). The scoring method was designed to focus on nucleotide sequence composition only. Guidelines addressing duplex thermodynamics and siRNA folding were excluded from the scoring method, however, were addressed in subsequent analysis. siRNA candidates that scored at least 75% (23 out of 30) were selecte.....
Document: The guidelines proposed by Ui-Tei, Reynolds and Amarzguioui were used to manually select the best siRNA candidates using a scoring method (Table 1 ). The scoring method was designed to focus on nucleotide sequence composition only. Guidelines addressing duplex thermodynamics and siRNA folding were excluded from the scoring method, however, were addressed in subsequent analysis. siRNA candidates that scored at least 75% (23 out of 30) were selected for further analysis.
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