Author: Xiaohua Chen; Binghong Zhao; Yueming Qu; Yurou Chen; Jie Xiong; Yong Feng; Dong Men; Qianchuan Huang; Ying Liu; Bo Yang; Jinya Ding; Feng Li
Title: Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely associated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients Document date: 2020_3_3
ID: g41pd9uz_23
Snippet: Remarkably, sharply increased IL-6 level was observed in critically ill patients, which was almost 10-folds higher than that of severe patients, moreover, all of the death cases exhibited extremely high IL-6 value(Table S1), suggesting that IL-6 might be an important biomarker of poor prognosis in COVID-19 patients. The extremely high level of IL-6 is a hallmark and an important driving force of cytokine storm 20 , which may cause multiple organs.....
Document: Remarkably, sharply increased IL-6 level was observed in critically ill patients, which was almost 10-folds higher than that of severe patients, moreover, all of the death cases exhibited extremely high IL-6 value(Table S1), suggesting that IL-6 might be an important biomarker of poor prognosis in COVID-19 patients. The extremely high level of IL-6 is a hallmark and an important driving force of cytokine storm 20 , which may cause multiple organs functional disability in critically ill patients 4 . Consistently, the parameters stand for the organ dysfunction, including TnT (troponin T), AST (aspartate transaminase), ALT (aspartate transaminase), CRE (serum creatinine), and BUN (blood urea nitrogen), all appear to be higher in critically ill patients compared with another two groups.
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