Inhibition of arterivirus RNA synthesis by cyclophilin inhibitors is counteracted by mutations in replicase transmembrane subunits

Adriaan H. de Wilde; A. Linda Boomaars-van der Zanden; Anja W. M. de Jong; Montserrat Barcéna; Eric J. Snijder; Clara C. Posthuma

The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/587261 doi: bioRxiv preprint The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/587261 doi: bioRxiv preprint The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/587261 doi: bioRxiv preprint well plates were infected with rEAV wt (control, black line) and the rEAV mutants rEAV-nsp2 H114R 807 (blue), rEAV QYA (red) and rEAV QYA -nsp2 H114R (green) in the presence of 0 to 50 µM ALV (A) or CsA 808 based quantification of RNA bands and is given relative to the abundance of RNA1, which was placed 831 at 100%. 832 833 All rights reserved. No reuse allowed without permission.