Author: Birlutiu, Victoria; Birlutiu, Rares Mircea
Title: Sepsis due to Streptococcus pneumoniae associated with secondary hemophagocytic lymphohistiocytosis in a splenectomized patient for spherocytosis: A case report Cord-id: t141h87g Document date: 2017_7_14
ID: t141h87g
Snippet: RATIONALE: Hemophagocytic lymphohistiocytosis (HLH) is a syndrome that is characterized by an inappropriate hyperinflammatory immune response – primary, as a consequence of a genetic defect of NK cells and cytotoxic T lymphocytes or – secondary, in the progression of infections, rheumatic or autoimmune diseases, malignancies or metabolic diseases. PATIENT CONCERNS: We present the case of a secondary HLH due to Streptococcus pneumoniae infection in a splenectomised patient for spherocytosis,
Document: RATIONALE: Hemophagocytic lymphohistiocytosis (HLH) is a syndrome that is characterized by an inappropriate hyperinflammatory immune response – primary, as a consequence of a genetic defect of NK cells and cytotoxic T lymphocytes or – secondary, in the progression of infections, rheumatic or autoimmune diseases, malignancies or metabolic diseases. PATIENT CONCERNS: We present the case of a secondary HLH due to Streptococcus pneumoniae infection in a splenectomised patient for spherocytosis, a 37-year-old patient who was splenectomised in childhood for spherocytosis, without immuneprophylaxis induced by antipneumococcal vaccine. OUTCOMES: He developed a severe pneumococcal sepsis associated with secondary HLH, with unfavorable outcome and death. LESSONS: To our knowledge, just 2 similar cases had been published in the literature, none in which the secondary HLH was the consequence of an invasive pneumococcal infection in a splenectomized patient for spherocytosis, and the association of splenectomy with HLH is surprizin.
Search related documents:
Co phrase search for related documents- acute liver failure and liver failure: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72
- acute liver failure and liver staining: 1
- acute liver failure and lymph node: 1
- acute liver failure renal failure acute and liver failure: 1, 2, 3, 4, 5
- acute respiratory failure and admission time: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32
- acute respiratory failure and liver failure: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31
- acute respiratory failure and lymph node: 1
- acute respiratory syndrome virus and admission time: 1, 2, 3, 4
- acute respiratory syndrome virus and liver failure: 1, 2, 3, 4, 5, 6
- acute respiratory syndrome virus and lymph node: 1
- admission time and liver failure: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- admission time and lymph node: 1, 2, 3
- liver failure and lymph node: 1
- liver staining and lymph node: 1, 2, 3
Co phrase search for related documents, hyperlinks ordered by date