Residual Lung Function Impairment Is Associated with Hyperventilation in Patients Recovered from Hospitalised COVID-19: A Cross-Sectional Study

Crisafulli, Ernesto; Gabbiani, Daniele; Magnani, Giulia; Dorelli, Gianluigi; Busti, Fabiana; Sartori, Giulia; Senna, Gianenrico; Girelli, Domenico; Investigators, on behalf of the RESPICOVID Study

Patients who have recovered from COVID-19 show persistent symptoms and lung function alterations with a restrictive ventilatory pattern. Few data are available evaluating an extended period of COVID-19 clinical progression. The RESPICOVID study has been designed to evaluate patients’ pulmonary damage previously hospitalised for interstitial pneumonia due to COVID-19. We focused on the arterial blood gas (ABG) analysis variables due to the initial observation that some patients had hypocapnia (arterial partial carbon dioxide pressure-PaCO(2) ≤ 35 mmHg). Therefore, we aimed to characterise patients with hypocapnia compared to patients with normocapnia (PaCO(2) > 35 mmHg). Data concerning demographic and anthropometric variables, clinical symptoms, hospitalisation, lung function and gas-analysis were collected. Our study comprised 81 patients, of whom 19 (24%) had hypocapnia as compared to the remaining (n = 62, 76%), and defined by lower levels of PaCO(2), serum bicarbonate (HCO(3−)), carbon monoxide diffusion capacity (DL(CO)), and carbon monoxide transfer coefficient (K(CO)) with an increased level of pH and arterial partial oxygen pressure (PaO(2)). K(CO) was directly correlated with PaCO(2) and inversely with pH. In our preliminary report, hypocapnia is associated with a residual lung function impairment in diffusing capacity. We focus on ABG analysis’s informativeness in the follow-up of post-COVID patients.