Author: Shuai Xia; Meiqin Liu; Chao Wang; Wei Xu; Qiaoshuai Lan; Siliang Feng; Feifei Qi; Linlin Bao; Lanying Du; Shuwen Liu; Chuan Qin; Fei Sun; Zhengli Shi; Yun Zhu; Shibo Jiang; Lu Lu
Title: Inhibition of SARS-CoV-2 infection (previously 2019-nCoV) by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion Document date: 2020_3_12
ID: j5bepvvw_16
Snippet: Strikingly, EK1C3 peptide with both the 3-amino acid linker "GSG" and the 244 PEG4-based spacer, exhibited 4-fold more potency than EK1C1. It is noteworthy that 245 changing "GSG" in EK1C3 to a longer 5-amino acid linker "GSGSG" significantly 246 increased the inhibitory potency of the hybrid molecule, and EK1C4 had IC 50 value of 247 1.3 nM, which was 43-fold more potent than EK1C1. These findings indicate that the 248 linker length has a signif.....
Document: Strikingly, EK1C3 peptide with both the 3-amino acid linker "GSG" and the 244 PEG4-based spacer, exhibited 4-fold more potency than EK1C1. It is noteworthy that 245 changing "GSG" in EK1C3 to a longer 5-amino acid linker "GSGSG" significantly 246 increased the inhibitory potency of the hybrid molecule, and EK1C4 had IC 50 value of 247 1.3 nM, which was 43-fold more potent than EK1C1. These findings indicate that the 248 linker length has a significant effect on the overall activity of lipopeptides. 249 author/funder. All rights reserved. No reuse allowed without permission.
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