Author: Chin-Yi Chu; Xing Qiu; Matthew N. McCall; Lu Wang; Anthony Corbett; Jeanne Holden-Wiltse; Christopher Slaunwhite; Qian Wang; Christopher Anderson; Alex Grier; Steven R. Gill; Gloria S. Pryhuber; Ann R. Falsey; David J. Topham; Mary T. Caserta; Edward E. Walsh; Thomas J Mariani
Title: Insufficiency in airway interferon activation defines clinical severity to infant RSV infection Document date: 2019_5_20
ID: bx49tbui_83
Snippet: We tested the effects of gain-and loss-of-function manipulation of IFN activity during RSV infection of PHLE cells (Fig 4B) . As expected, pretreatment of PHLE cells with type I (Figure 4B , C) and type III (Supplemental Figure 13 Figure 14) . Critically, but not surprisingly, RUX potentiated viral infection but did not block IFN ligand production (Fig. 4C) . These data indicate IFN signaling is necessary and sufficient to suppress the expression.....
Document: We tested the effects of gain-and loss-of-function manipulation of IFN activity during RSV infection of PHLE cells (Fig 4B) . As expected, pretreatment of PHLE cells with type I (Figure 4B , C) and type III (Supplemental Figure 13 Figure 14) . Critically, but not surprisingly, RUX potentiated viral infection but did not block IFN ligand production (Fig. 4C) . These data indicate IFN signaling is necessary and sufficient to suppress the expression of correlates of RSVinfected infant clinical severity in primary cultures of pediatric lung epithelial cells.
Search related documents:
Co phrase search for related documents- clinical severity and function loss: 1, 2
- clinical severity and IFN activity: 1, 2, 3, 4
- clinical severity and IFN ligand production: 1, 2
- clinical severity and ligand production: 1, 2
- clinical severity and lung epithelial cell: 1, 2, 3, 4
- clinical severity and rsv infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- clinical severity and viral infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- epithelial cell and function loss: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- epithelial cell and function loss gain: 1, 2
- epithelial cell and IFN activity: 1, 2, 3, 4, 5, 6, 7, 8, 9
- epithelial cell and IFN signal: 1, 2, 3, 4, 5, 6
- epithelial cell and lung epithelial cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- epithelial cell and primary culture: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22
- epithelial cell and rsv infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
- epithelial cell and viral infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- function loss and IFN activity: 1
- function loss and lung epithelial cell: 1
- function loss and rsv infection: 1
- function loss and viral infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
Co phrase search for related documents, hyperlinks ordered by date