Author: Bicheng Zhang; Xiaoyang Zhou; Chengliang Zhu; Fan Feng; Yanru Qiu; Jia Feng; Qingzhu Jia; Qibin Song; Bo Zhu; Jun Wang
Title: Immune phenotyping based on neutrophil-to-lymphocyte ratio and IgG predicts disease severity and outcome for patients with COVID-19 Document date: 2020_3_16
ID: 68193u0a_1
Snippet: Since December 2019, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has quickly spread across the world. 1 Approximately 20-30% of cases would develop severe illness, and some need further intervention in intensive care unit. Organ dysfunction including acute respiratory distress syndrome, shock, acute cardiac injury, and acute renal injury, could occur in severe cases with COVID-19, whi.....
Document: Since December 2019, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has quickly spread across the world. 1 Approximately 20-30% of cases would develop severe illness, and some need further intervention in intensive care unit. Organ dysfunction including acute respiratory distress syndrome, shock, acute cardiac injury, and acute renal injury, could occur in severe cases with COVID-19, which lead to poor clinical outcome. 2, 3 Following SARS-CoV-2 infection, a high viral load and overexuberant host immune response involving innate and acquired immunity, simultaneously contributes to the pathogenesis of COVID-19 and organ injury. [2] [3] [4] The activated host immunity is characterized as lymphopenia, cytokine release storm (CRS), and dysfunctional immune responses to virus-specific antigen. Increasing clinical data indicated that the neutrophil-to-lymphocyte ratio (NLR) was identified as a powerful predictive and prognostic indicator for severe COVID-19.
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