Selected article for: "immune response and innate response"
Author: Bicheng Zhang; Xiaoyang Zhou; Chengliang Zhu; Fan Feng; Yanru Qiu; Jia Feng; Qingzhu Jia; Qibin Song; Bo Zhu; Jun Wang
Title: Immune phenotyping based on neutrophil-to-lymphocyte ratio and IgG predicts disease severity and outcome for patients with COVID-19
  • Document date: 2020_3_16
    • ID: 68193u0a_16
    Snippet: Considering NLR is linked to innate immunity, and anti-IgG response is an indicator of acquired immunity, we stratified patients at late stage into four different immune response phenotypes: high NLR and high IgG levels (NLR hi IgG hi ), high NLR and low IgG levels (NLR hi IgG lo ), low NLR and high IgG levels (NLR lo IgG hi ), and low NLR and high IgG levels (NLR lo IgG lo ), according to NLR (cutoff: 3.04) and detected IgG levels (cutoff: 116.9.....
    Document: Considering NLR is linked to innate immunity, and anti-IgG response is an indicator of acquired immunity, we stratified patients at late stage into four different immune response phenotypes: high NLR and high IgG levels (NLR hi IgG hi ), high NLR and low IgG levels (NLR hi IgG lo ), low NLR and high IgG levels (NLR lo IgG hi ), and low NLR and high IgG levels (NLR lo IgG lo ), according to NLR (cutoff: 3.04) and detected IgG levels (cutoff: 116.9 AU/mL). Severity rates for patients with NLR hi IgG hi , NLR hi IgG lo , NLR lo IgG hi , and NLR lo IgG lo phenotype were 72.3% (34/47), 48.5% (16/33), 33.3% (12/36), and 15.6% (5/32), respectively (p<0.0001) (figure 2A).

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