Author: Eric Anthony Coomes; Hourmazd Haghbayan
Title: Interleukin-6 in COVID-19: A Systematic Review and Meta-Analysis Document date: 2020_4_3
ID: nadcsiii_43
Snippet: Most studies included in this review were rated at moderate or high risk of bias, reflecting generally low methodological quality. This was primarily driven by a lack of control for confounding, inconsistencies or unclarity of the context in which IL-6 measurements were performed, and potential for selection bias due to lack of consecutive patient enrolment. Lastly, we identified only a single, non-randomized, single-arm study investigating the e.....
Document: Most studies included in this review were rated at moderate or high risk of bias, reflecting generally low methodological quality. This was primarily driven by a lack of control for confounding, inconsistencies or unclarity of the context in which IL-6 measurements were performed, and potential for selection bias due to lack of consecutive patient enrolment. Lastly, we identified only a single, non-randomized, single-arm study investigating the effect of tocilizumab treatment in patients with COVID-19; while promising, this provides only low-level . CC-BY-NC-ND 4.0 International license It is made available under a author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
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