Author: Chin-Yi Chu; Xing Qiu; Matthew N. McCall; Lu Wang; Anthony Corbett; Jeanne Holden-Wiltse; Christopher Slaunwhite; Qian Wang; Christopher Anderson; Alex Grier; Steven R. Gill; Gloria S. Pryhuber; Ann R. Falsey; David J. Topham; Mary T. Caserta; Edward E. Walsh; Thomas J Mariani
Title: Insufficiency in airway interferon activation defines clinical severity to infant RSV infection Document date: 2019_5_20
ID: bx49tbui_7
Snippet: The AsPIRES (Assessing and Predicting Infant RSV Effects and Severity) study is a comprehensive study designed to identify factors associated with disease severity in full term healthy infants less than 10 months of age undergoing primary RSV infection. In this report we analyze gene expression of nasal respiratory epithelial cells, in addition to the influence of respiratory microbiota, in relation to illness severity during primary RSV infectio.....
Document: The AsPIRES (Assessing and Predicting Infant RSV Effects and Severity) study is a comprehensive study designed to identify factors associated with disease severity in full term healthy infants less than 10 months of age undergoing primary RSV infection. In this report we analyze gene expression of nasal respiratory epithelial cells, in addition to the influence of respiratory microbiota, in relation to illness severity during primary RSV infection. In addition, we describe the development of an in vitro model of RSV infection to explore the relationship between interferon activity, airway cell gene expression and productive RSV infection.
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