Author: Chin-Yi Chu; Xing Qiu; Matthew N. McCall; Lu Wang; Anthony Corbett; Jeanne Holden-Wiltse; Christopher Slaunwhite; Qian Wang; Christopher Anderson; Alex Grier; Steven R. Gill; Gloria S. Pryhuber; Ann R. Falsey; David J. Topham; Mary T. Caserta; Edward E. Walsh; Thomas J Mariani
Title: Insufficiency in airway interferon activation defines clinical severity to infant RSV infection Document date: 2019_5_20
ID: bx49tbui_77
Snippet: This revealed a surprising dichotomy between severe and non-severe subjects in expression of the IFN pathway genes identified in our analysis (Fig. 3B ). An association with severity was likely not identified in our prior analysis, as significant increases in expression noted in non-severe subjects were only noted during the first 3-4 days following the onset of clinical symptoms, whereas little to no evidence for interferon signaling was noted i.....
Document: This revealed a surprising dichotomy between severe and non-severe subjects in expression of the IFN pathway genes identified in our analysis (Fig. 3B ). An association with severity was likely not identified in our prior analysis, as significant increases in expression noted in non-severe subjects were only noted during the first 3-4 days following the onset of clinical symptoms, whereas little to no evidence for interferon signaling was noted in any subjects at later time points. qPCR validation of many of these genes supported a complex relationship between gene expression, clinical severity and the ontogeny of illness (Supplemental Table 3 ).
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