Author: Chin-Yi Chu; Xing Qiu; Matthew N. McCall; Lu Wang; Anthony Corbett; Jeanne Holden-Wiltse; Christopher Slaunwhite; Qian Wang; Christopher Anderson; Alex Grier; Steven R. Gill; Gloria S. Pryhuber; Ann R. Falsey; David J. Topham; Mary T. Caserta; Edward E. Walsh; Thomas J Mariani
Title: Insufficiency in airway interferon activation defines clinical severity to infant RSV infection Document date: 2019_5_20
ID: bx49tbui_31
Snippet: Both univariate and multivariate gene significance analyses were conducted by using the R package LIMMA 37 with a robust M-estimator 38 . Nine covariates (global respiratory severity score (GRSS), sex, race, gestational age, visit age, time since disease onset (time), smoking exposure, virus co-infection, and bacterial colonization) were investigated via univariate analyses, in which the association between a single covariate and gene expression .....
Document: Both univariate and multivariate gene significance analyses were conducted by using the R package LIMMA 37 with a robust M-estimator 38 . Nine covariates (global respiratory severity score (GRSS), sex, race, gestational age, visit age, time since disease onset (time), smoking exposure, virus co-infection, and bacterial colonization) were investigated via univariate analyses, in which the association between a single covariate and gene expression was estimated. Following the univariate analyses, we conducted a multivariate analysis that included the same nine significant clinical variables. In addition, we also tried a simplified multivariate regression model with the five most significant All rights reserved. No reuse allowed without permission.
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