Author: Chin-Yi Chu; Xing Qiu; Matthew N. McCall; Lu Wang; Anthony Corbett; Jeanne Holden-Wiltse; Christopher Slaunwhite; Qian Wang; Christopher Anderson; Alex Grier; Steven R. Gill; Gloria S. Pryhuber; Ann R. Falsey; David J. Topham; Mary T. Caserta; Edward E. Walsh; Thomas J Mariani
Title: Insufficiency in airway interferon activation defines clinical severity to infant RSV infection Document date: 2019_5_20
ID: bx49tbui_5
Snippet: Respiratory Syncytial Virus (RSV), a negative strand RNA virus in the Pneumoviridae family, is the most important cause of respiratory tract infection during infancy, causing annual winter outbreaks in the US [1] [2] [3] [4] [5] [6] . In the US approximately half of the 4 million newborns are infected during their first winter with 1-3% hospitalized and an additional 4-7% and 10-16% seen in emergency departments or physician offices, respectively.....
Document: Respiratory Syncytial Virus (RSV), a negative strand RNA virus in the Pneumoviridae family, is the most important cause of respiratory tract infection during infancy, causing annual winter outbreaks in the US [1] [2] [3] [4] [5] [6] . In the US approximately half of the 4 million newborns are infected during their first winter with 1-3% hospitalized and an additional 4-7% and 10-16% seen in emergency departments or physician offices, respectively, for RSV infections 7 . Mortality is uncommon in the US (~50 deaths annually); however, in developing countries it is estimated that annually RSV causes 118 thousand deaths, 6 million cases of severe acute lower respiratory illness and 3 million hospitalizations in children under 5 years of age 8, 9 . Currently there is no available vaccine for RSV in infants, although several candidate vaccines are in clinical trials.
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