Author: Chin-Yi Chu; Xing Qiu; Matthew N. McCall; Lu Wang; Anthony Corbett; Jeanne Holden-Wiltse; Christopher Slaunwhite; Qian Wang; Christopher Anderson; Alex Grier; Steven R. Gill; Gloria S. Pryhuber; Ann R. Falsey; David J. Topham; Mary T. Caserta; Edward E. Walsh; Thomas J Mariani
Title: Insufficiency in airway interferon activation defines clinical severity to infant RSV infection Document date: 2019_5_20
ID: bx49tbui_6
Snippet: Long established major risk factors for severe illness include prematurity, bronchopulmonary dysplasia, cyanotic heart disease, neuromuscular disease, and immune compromise 4, 10 . However, approximately 70% of hospitalized infants in the US have no overt risk factors for severe illness. Although young age at infection, environmental influences such as tobacco smoke exposure, viral load and strain, low levels of maternally derived RSV-neutralizin.....
Document: Long established major risk factors for severe illness include prematurity, bronchopulmonary dysplasia, cyanotic heart disease, neuromuscular disease, and immune compromise 4, 10 . However, approximately 70% of hospitalized infants in the US have no overt risk factors for severe illness. Although young age at infection, environmental influences such as tobacco smoke exposure, viral load and strain, low levels of maternally derived RSV-neutralizing antibody, as well as a multitude of genetic host factors have been associated with severe disease in some but not all studies 4,11-22 . likely to play pivotal roles in both eliminating virus replication as well as enhancing or moderating the inflammatory response 31, 32 .
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