Selected article for: "biological process and gene expression"
Author: Xiang He; Lei Zhang; Qin Ran; Anying Xiong; Junyi Wang; Dehong Wu; Feng Chen; Guoping Li
Title: Integrative Bioinformatics Analysis Provides Insight into the Molecular Mechanisms of 2019-nCoV
  • Document date: 2020_2_5
    • ID: mjhez5im_14
    Snippet: Considering higher expression of ACE2 was involved in mediating inflammatory responses, immune activities, and viral replication in both healthy individuals and infected cells, we further explored protein-protein regulation network in viral activity-related proteins and cytokine secretion, respectively. We extracted the viral activity-associated and cytokine secretion-associated proteins from the Gene ontology (GO) biological process gmt file. Co.....
    Document: Considering higher expression of ACE2 was involved in mediating inflammatory responses, immune activities, and viral replication in both healthy individuals and infected cells, we further explored protein-protein regulation network in viral activity-related proteins and cytokine secretion, respectively. We extracted the viral activity-associated and cytokine secretion-associated proteins from the Gene ontology (GO) biological process gmt file. Construction of the Protein-protein interaction (PPI) showed that these proteins were tightly interactive among each other and we here exhibited the most significant PPI. In terms of viral activity, we found that "viral gene expression" proteins such as RPS3, RPS8 and PRS25 were the most important genes in the PPI network. In addition, VCP, LARP1, UBA52, PRKN, EIF3A and EIF3L

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