Selected article for: "model system and virus infection"
Author: Chin-Yi Chu; Xing Qiu; Matthew N. McCall; Lu Wang; Anthony Corbett; Jeanne Holden-Wiltse; Christopher Slaunwhite; Qian Wang; Christopher Anderson; Alex Grier; Steven R. Gill; Gloria S. Pryhuber; Ann R. Falsey; David J. Topham; Mary T. Caserta; Edward E. Walsh; Thomas J Mariani
Title: Insufficiency in airway interferon activation defines clinical severity to infant RSV infection
  • Document date: 2019_5_20
    • ID: bx49tbui_88
    Snippet: We also leveraged a novel, physiological in vitro system that emulates the cellular responses to viral infection in pediatric human lung epithelial cells (PHLE). Using this model system, we validated the relationship between RSV-induced IFN-related intracellular signaling and the severity of infection, in relevant target cells for this virus (Fig. 5) ......
    Document: We also leveraged a novel, physiological in vitro system that emulates the cellular responses to viral infection in pediatric human lung epithelial cells (PHLE). Using this model system, we validated the relationship between RSV-induced IFN-related intracellular signaling and the severity of infection, in relevant target cells for this virus (Fig. 5) .

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