Author: Chin-Yi Chu; Xing Qiu; Matthew N. McCall; Lu Wang; Anthony Corbett; Jeanne Holden-Wiltse; Christopher Slaunwhite; Qian Wang; Christopher Anderson; Alex Grier; Steven R. Gill; Gloria S. Pryhuber; Ann R. Falsey; David J. Topham; Mary T. Caserta; Edward E. Walsh; Thomas J Mariani
Title: Insufficiency in airway interferon activation defines clinical severity to infant RSV infection Document date: 2019_5_20
ID: bx49tbui_96
Snippet: We should emphasize that our primary observation is not that severity is associated with IFN ligand production, but with estimated levels of signaling activation in the airway. This distinction could be due to low levels of ligand production, even in infants with mild clinical symptoms. However, we could show differences in IFN ligand expression at both the RNA and protein levels (Fig. 1) , after our initial discovery phase of RNAseq data analysi.....
Document: We should emphasize that our primary observation is not that severity is associated with IFN ligand production, but with estimated levels of signaling activation in the airway. This distinction could be due to low levels of ligand production, even in infants with mild clinical symptoms. However, we could show differences in IFN ligand expression at both the RNA and protein levels (Fig. 1) , after our initial discovery phase of RNAseq data analysis. Conversely, the distinction could support the logical conclusion that All rights reserved. No reuse allowed without permission.
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