Immature platelet fraction: is a novel early predictive marker for disease severity in patients with Covid-19 pneumonia?

Incir, Said Komesli Zeynep Baygul Arzu Tasdemir Zeynep Atam Palaoglu Kerim Erhan Kant Hatice Kapmaz Mahir Tekin Suda Kilic Alparslan Dagel Tuncay Okan Ayse Somay Kayra Akpinar Timur Selcuk

In many diseases, immature platelet fraction (IPF%) is related to coagulopathy and poor outcome. This study aimed to investigate the predictive value of IPF% for the severity of pneumonia in patients with Coronavirus Disease 2019 (COVID-19).A total of 154 patients with COVID‐19 infections were included. The patients were divided into two groups according to the severity of pneumonia (severe and non-severe) regarding their oxygen demand.Given laboratory parameters, the median IPF% was significantly higher in the severe group (11.9 vs. 3.9%, p<0.001). Mean platelet volume (p<0.001), platelet-large cell ratio (p=0.001), platelet distribution width (p=0.001), D-Dimer (p<0.001), INR (p=0.003), and aPTT (p=0.007) were also found to be significantly higher in the severe group. Moreover, IPF (p=0.014, Odds ratio = 2.000, 95%CI: 1.149-3.482) was an independent predictor for the severity. The curve value from receiver operating characteristics was 0.879 (p<0.001, 95%CI: 0.784-0.943) for determining the severity of pneumonia. IPF% had a sensitivity and specificity value of 69.5 and 92.4% to detect the disease’s severity.IPF% is an independent predictor for the severity of COVID-19 pneumonia. Assessment of IPF% may both help to early determine high-risk patients with COVID-19 and to alert the physicians. (English) [ABSTRACT FROM AUTHOR] Pek çok hastalıkta, immatür platelet fraksiyonu (%ÍPF), koagülopati ve kötü sonuçla iliÅŸkilidir. Bu çalışma, Coronavirus Hastalığı 2019 (COVID-19) olan hastalarda pnömoni ÅŸiddeti için %ÍPF’nin prediktif deÄŸerini araÅŸtırmayı amaçladı.COVID-19 enfeksiyonu olan toplam 154 hasta dahil edildi. Hastalar, oksijen ihtiyaçları göz önüne alınarak pnömoni ÅŸiddetine göre (ağır ve ağır olmayan) iki gruba ayrıldı.Laboratuvar parametrelerine bakıldığında, medyan ÍPF yüzdesi ağır grupta anlamlı olarak daha yüksekti (%11.9′a karşı %3.9, p<0.001). Ortalama trombosit hacmi (p<0.001), trombosit-büyük hücre oranı (p=0.001), trombosit dağılım geniÅŸliÄŸi (p=0.001), D-Dimer (p<0.001), ÍNR (p=0.003) ve aPTT (p=0.007) ağır grupta anlamlı olarak daha yüksek bulundu. Ayrıca, ÍPF (p=0.014, Odds oranı = 2.000, %95 CI: 1.149-3.482) hastalık ÅŸiddeti için bağımsız bir öngördürücü olarak bulundu. Algılayıcı iÅŸletim eÄŸrisinden gelen eÄŸri deÄŸeri, pnömoni ÅŸiddetini belirlemek için 0.879 (p<0.001, %95 CI: 0.784-0.943) idi. ÍPF, hastalığın ÅŸiddetini saptamak için %69.5′lik duyarlılık ve %92.4′lük özgüllük deÄŸerine sahipti.ÍPF, COVID-19 pnömonisinin ÅŸiddeti için bağımsız bir öngörücüdür. %ÍPF’nin deÄŸerlendirilmesi, hem COVID-19′lu yüksek riskli hastaları erken belirlemeye hem de hekimleri uyarmaya yardımcı olabilir. (Turkish) [ABSTRACT FROM AUTHOR] Copyright of Turkish Journal of Biochemistry / Turk Biyokimya Dergisi is the property of De Gruyter and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)