Author: Saba Ismail; Sajjad Ahmad; Syed Sikander Azam
Title: Immuno-informatics Characterization SARS-CoV-2 Spike Glycoprotein for Prioritization of Epitope based Multivalent Peptide Vaccine Document date: 2020_4_12
ID: 3jmo35jc_22
Snippet: Prioritized T cell epitopes derived from B cells were fused together tandemly by AAY linkers to make a multi-epitope peptide (MEP). AAY linker avoid formation of junctional epitopes and as such enhance epitope presentation [87] . To the N-terminal of MEP, EAAAK linker was added to attach β-defensin as an adjuvant leading to the design of a MEPVC. The MEPVC is schematically shown in Fig.5A . MEPVC offers many advantages compared to a separate ant.....
Document: Prioritized T cell epitopes derived from B cells were fused together tandemly by AAY linkers to make a multi-epitope peptide (MEP). AAY linker avoid formation of junctional epitopes and as such enhance epitope presentation [87] . To the N-terminal of MEP, EAAAK linker was added to attach β-defensin as an adjuvant leading to the design of a MEPVC. The MEPVC is schematically shown in Fig.5A . MEPVC offers many advantages compared to a separate antigenic peptide. Such vaccines induce both CD4+ and CD8+ responses and the antigens optimization are optimal. EAAAK is a rigid spacer and allow separation of the attached domain and promoting efficient immune processing of the epitopes [88] . β-defensins are potent immune adjuvants as they are capable of significantly enhancing production of lymphokines resulting into antigen-specific Ig production and T cell-dependent cellular immunity.
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