Selected article for: "bacterial infection and inflammatory response"
Author: Yue-qiang Fu; Yue-lin Sun; Si-wei Lu; Yang Yang; Yi Wang; Feng Xu
Title: Impact of blood analysis and immune function on the prognosis of patients with COVID-19
  • Document date: 2020_4_22
    • ID: a822exap_44
    Snippet: is the (which was not peer-reviewed) The copyright holder for this preprint . https://doi.org/10.1101/2020.04. 16.20067587 doi: medRxiv preprint However, the admission (baseline) leukocyte count, neutrophil percentage, and neutrophil count of the death group were all significantly higher than that of the survivors. Chang et al. [2] reported that an initial neutrophil count >7000/mL was an independent risk factor for death in patients with SARS. S.....
    Document: is the (which was not peer-reviewed) The copyright holder for this preprint . https://doi.org/10.1101/2020.04. 16.20067587 doi: medRxiv preprint However, the admission (baseline) leukocyte count, neutrophil percentage, and neutrophil count of the death group were all significantly higher than that of the survivors. Chang et al. [2] reported that an initial neutrophil count >7000/mL was an independent risk factor for death in patients with SARS. Singapore scholars also concluded that neutropenia predicted poor prognosis in SARS [3] . The leukocyte counts of severe patients with COVID-19 were significantly higher than those of non-severe patients [8] [9] [10] . For the present patients with COVID-19, we found that neutrophil count was above the higher limitation of normal range in 12(85.71%) dead patients and an initial elevated neutrophil count was an independent risk factor of mortality. This significant elevation of neutrophil count in the death group, may reflect a strong inflammatory response toward viral infection, or a possible combination with bacterial infection. The specific mechanism needs further study.

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