Author: Jakub M Bartoszewicz; Anja Seidel; Bernhard Y Renard
Title: Interpretable detection of novel human viruses from genome sequencing data Document date: 2020_1_30
ID: ac00tai9_2
Snippet: Screening against potentially dangerous subsequences before their synthesis may also be used as a way of ensuring responsible research in synthetic biology. While potentially useful in some applications, engineering of viral genomes could also pose a biosecurity and biosafety threat. Two controversial studies modified the influenza A/H5N1 ("bird flu") virus to be airborne transmissible in mammals (Herfst et al., 2012; Imai et al., 2012) . A possi.....
Document: Screening against potentially dangerous subsequences before their synthesis may also be used as a way of ensuring responsible research in synthetic biology. While potentially useful in some applications, engineering of viral genomes could also pose a biosecurity and biosafety threat. Two controversial studies modified the influenza A/H5N1 ("bird flu") virus to be airborne transmissible in mammals (Herfst et al., 2012; Imai et al., 2012) . A possibility of modifying coronaviruses to enhance their virulence triggered calls for a moratorium on this kind of research (Lipsitch & Inglesby, 2014) . Synthesis of an infectious horsepox virus closely related to the smallpox-causing Variola virus (Noyce et al., 2018) caused a public uproar and calls for intensified discussion on risk control in synthetic biology (Thiel, 2018) .
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