Selected article for: "search strategy and trial registry"
Author: Eric Anthony Coomes; Hourmazd Haghbayan
Title: Interleukin-6 in COVID-19: A Systematic Review and Meta-Analysis
  • Document date: 2020_4_3
    • ID: nadcsiii_9
    Snippet: We designed a high sensitivity search strategy combining free text and keyword search term synonym clusters for COVID-19, combined with clusters for either IL-6 or tocilizumab. We then systematically searched for published articles in Ovid Medline Embase, pre-publication manuscripts in pre-print servers (Biorxiv, Medrxiv, and Chinxiv), and Google Scholar, and for planned trials in clinical trial registries (clinicaltrials.gov and the Chinese Clin.....
    Document: We designed a high sensitivity search strategy combining free text and keyword search term synonym clusters for COVID-19, combined with clusters for either IL-6 or tocilizumab. We then systematically searched for published articles in Ovid Medline Embase, pre-publication manuscripts in pre-print servers (Biorxiv, Medrxiv, and Chinxiv), and Google Scholar, and for planned trials in clinical trial registries (clinicaltrials.gov and the Chinese Clinical Trial Registry). All searches spanned January 1, 2019 to March 15, 2020 ; no exclusions were made for language, disease severity, or outcomes reported. We then conducted an expanded Ovid Medline and Embase database search from January 1, 2020 to March 15, 2020 for all published cohort studies reporting COVID-19 patient characteristics and outcomes (see Appendix for full search strategy) to ensure all studies reporting IL-6 levels in COVID-19 were identified. Reference lists of all included articles were also reviewed for potential eligibility of citations.

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