Potential for elimination of SAR‐CoV‐2 through vaccination as inspired by elimination of multiple influenza viruses through natural pandemics or mass vaccination

Chen, Ji‐Ming; Sun, Ying‐Xue; Chen, Ji‐Wang

The ongoing pandemic of coronavirus disease 2019 (COVID‐19) caused by the novel virus SARS‐CoV‐2 has claimed many lives worldwide. To combat the pandemic, multiple types of vaccines are under development with unprecedented rapidity. Theoretically, the future vaccination against COVID‐19 may fall into long‐term costly guerrilla warfare between SARS‐CoV‐2 and humans. Elimination of SARS‐CoV‐2 through vaccination to avoid the potential long‐term costly guerrilla warfare, if possible, is highly desired and worth intensive consideration. Human influenza pandemics emerging in 1957, 1968, and 2009 established strong global herd immunity and led to elimination of three human influenza viruses which circulated worldwide for years before the pandemics. Moreover, both clade 7.2 of subtype H5 highly pathogenic avian influenza virus and subtype H7N9 avian influenza virus circulated in poultry in China for years, and they have been virtually eliminated through mass vaccination in recent years. These facts suggested that rapid establishment of global herd immunity through mass vaccination using a proper vaccine could eliminate SARS‐CoV‐2. The coming two years is the golden time for the elimination through vaccination which requires tremendous national and international collaboration. This review also prioritized the efficacy of vaccines for COVID‐19 and elucidated the importance for development of more live vaccines for COVID‐19. This article is protected by copyright. All rights reserved.