Author: Christoph Muus; Malte D Luecken; Gokcen Eraslan; Avinash Waghray; Graham Heimberg; Lisa Sikkema; Yoshihiko Kobayashi; Eeshit Dhaval Vaishnav; Ayshwarya Subramanian; Christopher Smillie; Karthik Jagadeesh; Elizabeth Thu Duong; Evgenij Fiskin; Elena Torlai Triglia; Christophe Becavin; Meshal Ansari; Peiwen Cai; Brian Lin; Justin Buchanan; Sijia Chen; Jian Shu; Adam L Haber; Hattie Chung; Daniel T Montoro; Taylor Adams; Hananeh Aliee; Samuel J Allon; Zaneta Andrusivova; Ilias Angelidis; Orr Ashenberg; Kevin Bassler; Christophe Becavin; Inbal Benhar; Joseph Bergenstrahle; Ludvig Bergenstrahle; Liam Bolt; Emelie Braun; Linh T Bui; Mark Chaffin; Evgeny Chichelnitskiy; Joshua Chiou; Thomas M Conlon; Michael S Cuoco; Marie Deprez; David S Fischer; Astrid Gillich; Joshua Gould; Minzhe Guo; Austin J Gutierrez; Arun C Habermann; Tyler Harvey; Peng He; Xiaomeng Hou; Lijuan Hu; Alok Jaiswal; Peiyong Jiang; Theodoros Kapellos; Christin S Kuo; Ludvig Larsson; Michael A Leney-Greene; Kyungtae Lim; Monika Litvinukova; Ji Lu; Leif S Ludwig; Wendy Luo; Henrike Maatz; Elo Maddissoon; Lira Mamanova; Kasidet Manakongtreecheep; Charles-Hugo Marquette; Ian Mbano; Alexi M McAdams; Ross J Metzger; Ahmad N Nabhan; Sarah K Nyquist; Jose Ordovas-Montanes; Lolita Penland; Olivier B Poirion; Segio Poli; CanCan Qi; Daniel Reichart; Ivan Rosas; Jonas Schupp; Rahul Sinha; Rene V Sit; Kamil Slowikowski; Michal Slyper; Neal Smith; Alex Sountoulidis; Maximilian Strunz; Dawei Sun; Carlos Talavera-Lopez; Peng Tan; Jessica Tantivit; Kyle J Travaglini; Nathan R Tucker; Katherine Vernon; Marc H Wadsworth; Julia Waldman; Xiuting Wang; Wenjun Yan; Ali Onder Yildirim; William Zhao; Carly G K Ziegler; Aviv Regev
Title: Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells Document date: 2020_4_20
ID: nkql7h9x_42
Snippet: Because different host proteases may contribute to different stages of the viral life cycle 107,111 , we also examined the prevalence of ACE2 + TMPRSS2 + PCSK + triple-positive cells (TPs) in the lung dataset. ACE2 + TMPRSS2 + PCSK7 + were the main triple positive cells in multiciliated (0.75%) and secretory cells (0.72%) of proximal airways, and ACE2 + TMPRSS2 + FURIN + TPs were the most common within AT2 cells (0.36%) (Extended Data Fig. 14k) ......
Document: Because different host proteases may contribute to different stages of the viral life cycle 107,111 , we also examined the prevalence of ACE2 + TMPRSS2 + PCSK + triple-positive cells (TPs) in the lung dataset. ACE2 + TMPRSS2 + PCSK7 + were the main triple positive cells in multiciliated (0.75%) and secretory cells (0.72%) of proximal airways, and ACE2 + TMPRSS2 + FURIN + TPs were the most common within AT2 cells (0.36%) (Extended Data Fig. 14k) . Finally, when we examined all known human proteases for co-expression with ACE2 in major lung epithelial cell types (Fig. 6f) , we recovered cathepsins (CTSB, CTSC, CTSD, CTSL, CTSS), proteasome subunits (e.g. PSMB2, PSMB4, PSMB5), and complement proteases (C1R, C2, CFI) (Fig. 6f, Extended Data Fig. 15 ), the latter also captured in our programs above (Fig. 4) .
Search related documents:
Co phrase search for related documents- cell type and epithelial cell type: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- cell type and host protease: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
- cell type and human protease: 1, 2, 3, 4, 5
- cell type and life cycle: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17
- cell type and lung dataset: 1, 2, 3, 4
- cell type and lung epithelial cell type: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16
- cell type and positive cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23
- cell type and proteasome subunit: 1
- cell type and secretory cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17
- complement protease and host protease: 1, 2
- complement protease and human protease: 1, 2
- different host protease and host protease: 1, 2
- different stage and life cycle: 1, 2, 3, 4, 5, 6
- epithelial cell type and human protease: 1
- epithelial cell type and lung epithelial cell type: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16
- epithelial cell type and secretory cell: 1, 2
- host protease and human protease: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
- host protease and life cycle: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- human protease and secretory cell: 1, 2
Co phrase search for related documents, hyperlinks ordered by date