Author: Heaton, S. M.
Title: Exportin-1 (XPO1, CRM1) inhibitors for the management of viral infection Cord-id: agfc5sy2 Document date: 2021_1_1
ID: agfc5sy2
Snippet: A therapeutic gap exists between new emerging infectious diseases and effective treatments. Targeting host factors involved in the replication strategies of evolutionarily diverse viruses may bridge this gap. Exportin-1 (XPO1, also termed chromosome region maintenance 1 [CRM1]) is a cellular nuclear export receptor for cellular and viral protein and ribonucleoprotein cargos harboring a nuclear export signal. XPO1 inhibition suppresses replication of numerous evolutionarily diverse viruses and on
Document: A therapeutic gap exists between new emerging infectious diseases and effective treatments. Targeting host factors involved in the replication strategies of evolutionarily diverse viruses may bridge this gap. Exportin-1 (XPO1, also termed chromosome region maintenance 1 [CRM1]) is a cellular nuclear export receptor for cellular and viral protein and ribonucleoprotein cargos harboring a nuclear export signal. XPO1 inhibition suppresses replication of numerous evolutionarily diverse viruses and one XPO1 inhibitor has entered clinical trials for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the etiologic agent of coronavirus disease-2019 (COVID-19). This review examines current and potential strategies and challenges in targeting XPO1-mediated nuclear export for treating established, emerging and future virus infections. © 2021 Clarivate Analytics.
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