Author: Manish Tiwari; Divya Mishra
Title: Investigating the genomic landscape in novel coronavirus (2019-nCoV) genomes to identify non-synonymous mutations for use in diagnosis and drug design Document date: 2020_4_18
ID: f0z8gcws_18
Snippet: Mutations were most prevalent in the spike region followed by Nsp2, Nsp3 and ORF9 (N) ( Table 5 ). Spike region determines the specific binding to host receptor and initiation of viral replication. This region is reported to be the most potent and indispensable for viral attachment and entry into host system. The RRAR amino acids found only in the human CoVs spike region has proved to be essential for binding to host receptor (Walls et al., 2020).....
Document: Mutations were most prevalent in the spike region followed by Nsp2, Nsp3 and ORF9 (N) ( Table 5 ). Spike region determines the specific binding to host receptor and initiation of viral replication. This region is reported to be the most potent and indispensable for viral attachment and entry into host system. The RRAR amino acids found only in the human CoVs spike region has proved to be essential for binding to host receptor (Walls et al., 2020) .
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