Selected article for: "low sequence conservation and sequence conservation"
Author: Ilda D’Annessa; Filippo Marchetti; Giorgio Colombo
Title: Differential Antibody Recognition by Novel SARS-CoV-2 and SARS-CoV Spike Protein Receptor Binding Domains: Mechanistic Insights and Implications for the Design of Diagnostics and Therapeutics
  • Document date: 2020_3_14
    • ID: c08ptb1o_11
    Snippet: Importantly, the predicted epitopes for SARS-CoV spike RBD show a good degree of overlap with the epitopes mapped for neutralizing Ab 80R 16 , S230 17 and m396 18 , providing a relevant validation of our approach. However, in spite of the high degree of structural similarity between the two spike proteins, these mAbs failed to bind SARS-CoV-2 RBD, probably due to the low degree of sequence conservation in the regions contacted by these antibodies.....
    Document: Importantly, the predicted epitopes for SARS-CoV spike RBD show a good degree of overlap with the epitopes mapped for neutralizing Ab 80R 16 , S230 17 and m396 18 , providing a relevant validation of our approach. However, in spite of the high degree of structural similarity between the two spike proteins, these mAbs failed to bind SARS-CoV-2 RBD, probably due to the low degree of sequence conservation in the regions contacted by these antibodies. The fact that most of the SARS-CoVdirected mAbs are not reactive against the novel betacoronavirus once more highlights the need to discover specific epitopes in SARS-CoV-2.

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