Author: Manish Tiwari; Divya Mishra
Title: Investigating the genomic landscape in novel coronavirus (2019-nCoV) genomes to identify non-synonymous mutations for use in diagnosis and drug design Document date: 2020_4_18
ID: f0z8gcws_25
Snippet: were observed in hCoVs. Change of isoleucine to valine in polymerase subunit PB2 of influenza virus resulted in critically enhanced activity of reconstituted polymerase complex (Rolling et al., 2009 ) and M to I substitution in HIV-1 reverse transcriptase imparted resistance to nucleoside analog 2′,3′-dideoxy-3′thiacytidine (3TC) (Julias et al., 2004) ......
Document: were observed in hCoVs. Change of isoleucine to valine in polymerase subunit PB2 of influenza virus resulted in critically enhanced activity of reconstituted polymerase complex (Rolling et al., 2009 ) and M to I substitution in HIV-1 reverse transcriptase imparted resistance to nucleoside analog 2′,3′-dideoxy-3′thiacytidine (3TC) (Julias et al., 2004) .
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