Selected article for: "liver kidney and lung kidney"
Author: Christoph Muus; Malte D Luecken; Gokcen Eraslan; Avinash Waghray; Graham Heimberg; Lisa Sikkema; Yoshihiko Kobayashi; Eeshit Dhaval Vaishnav; Ayshwarya Subramanian; Christopher Smillie; Karthik Jagadeesh; Elizabeth Thu Duong; Evgenij Fiskin; Elena Torlai Triglia; Christophe Becavin; Meshal Ansari; Peiwen Cai; Brian Lin; Justin Buchanan; Sijia Chen; Jian Shu; Adam L Haber; Hattie Chung; Daniel T Montoro; Taylor Adams; Hananeh Aliee; Samuel J Allon; Zaneta Andrusivova; Ilias Angelidis; Orr Ashenberg; Kevin Bassler; Christophe Becavin; Inbal Benhar; Joseph Bergenstrahle; Ludvig Bergenstrahle; Liam Bolt; Emelie Braun; Linh T Bui; Mark Chaffin; Evgeny Chichelnitskiy; Joshua Chiou; Thomas M Conlon; Michael S Cuoco; Marie Deprez; David S Fischer; Astrid Gillich; Joshua Gould; Minzhe Guo; Austin J Gutierrez; Arun C Habermann; Tyler Harvey; Peng He; Xiaomeng Hou; Lijuan Hu; Alok Jaiswal; Peiyong Jiang; Theodoros Kapellos; Christin S Kuo; Ludvig Larsson; Michael A Leney-Greene; Kyungtae Lim; Monika Litvinukova; Ji Lu; Leif S Ludwig; Wendy Luo; Henrike Maatz; Elo Maddissoon; Lira Mamanova; Kasidet Manakongtreecheep; Charles-Hugo Marquette; Ian Mbano; Alexi M McAdams; Ross J Metzger; Ahmad N Nabhan; Sarah K Nyquist; Jose Ordovas-Montanes; Lolita Penland; Olivier B Poirion; Segio Poli; CanCan Qi; Daniel Reichart; Ivan Rosas; Jonas Schupp; Rahul Sinha; Rene V Sit; Kamil Slowikowski; Michal Slyper; Neal Smith; Alex Sountoulidis; Maximilian Strunz; Dawei Sun; Carlos Talavera-Lopez; Peng Tan; Jessica Tantivit; Kyle J Travaglini; Nathan R Tucker; Katherine Vernon; Marc H Wadsworth; Julia Waldman; Xiuting Wang; Wenjun Yan; Ali Onder Yildirim; William Zhao; Carly G K Ziegler; Aviv Regev
Title: Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells
  • Document date: 2020_4_20
    • ID: nkql7h9x_41
    Snippet: We next examined PCSKs expression and co-expression with ACE2 across lung cell subsets (Fig. 6c, Extended Data Fig. 14f) . FURIN, PCSK5 and PCSK7 were broadly expressed across multiple lung cell types, and PCSK1 and PCSK2 were largely restricted to neuroendocrine cells, as previously reported 107 , with PCSK2 further detected in 11.2% of AT2 cells (Fig. 6d, Extended Data Fig. 14g ). In many cell subsets we observed dual expression with ACE2 at .....
    Document: We next examined PCSKs expression and co-expression with ACE2 across lung cell subsets (Fig. 6c, Extended Data Fig. 14f) . FURIN, PCSK5 and PCSK7 were broadly expressed across multiple lung cell types, and PCSK1 and PCSK2 were largely restricted to neuroendocrine cells, as previously reported 107 , with PCSK2 further detected in 11.2% of AT2 cells (Fig. 6d, Extended Data Fig. 14g ). In many cell subsets we observed dual expression with ACE2 at fractions comparable to or higher than those of ACE2 + TMPRSS2 + cells (Fig. 6e, Extended Data Fig. 14h ). These include AT2 cells (ACE2 + TMPRSS2 + , ACE2 + FURIN + and ACE2 + PCSK2 + at 0.90%, 0.78%, and 0.56%, Fig. 6e) ; multiciliated cells in the proximal airway (ACE2 + TMPRSS2 + , ACE2 + FURIN + , ACE2 + PCSK7 + , and ACE2 + PCSK5 + at 0.91%, 0.37%, 1.02%, and 0.91%), and basal cells (ACE2 + TMPRSS2 + , ACE2 + FURIN + , and ACE2 + PCSK7 + at 0.19%, 0.21%, and 0.74%). Co-expression is present across tissues in addition to the lung (Extended Data Fig. 14i,j) , including the liver, ileum, kidney and nasal airways, with the highest percentages of ACE2 + PCSK + dual positive cells in nasal airways (ACE2 + PCSK7 + 1.36%, ACE2 + FURIN + 0.67%), bladder (ACE2 + PCSK5 + 0.45%) and testis (ACE2 + PCSK7 + 0.41%).

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