Author: David E. Ochayon; Ayad Ali; Pablo C. Alarcon; Durga Krishnamurthy; Leah C. Kottyan; Michael Borchers; Stephen N. Waggoner
Title: Interleukin-33 promotes type 1 cytokine expression via p38 MAPK in human natural killer cells Document date: 2019_9_20
ID: iuhhuy53_3
Snippet: In the present study, we confirm that primary human NK cells treated with a combination of IL-33 and IL-12 ex vivo produce high levels of IFN-ï§ 16 ï€¬ï€ and we extend this observation to near physiological picogram concentrations of these cytokines. Mechanistically, we implicate the p38 mitogen-activated protein kinase (MAPK) pathway in IL-33-mediated enhancement of IL-12-induced responses of human NK cells and uncover a role for ADAM17 in enha.....
Document: In the present study, we confirm that primary human NK cells treated with a combination of IL-33 and IL-12 ex vivo produce high levels of IFN-ï§ 16 ï€¬ï€ and we extend this observation to near physiological picogram concentrations of these cytokines. Mechanistically, we implicate the p38 mitogen-activated protein kinase (MAPK) pathway in IL-33-mediated enhancement of IL-12-induced responses of human NK cells and uncover a role for ADAM17 in enhanced release of TNF under these stimulatory conditions. These data provide mechanistic insights into how IL-33-rich inflammatory milieus may directly enhance proinflammatory activities of NK cells.
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