Author: Mathilde ROUMIER; Romain PAULE; Matthieu GROH; Alexandre VALLEE; Felix ACKERMANN
Title: Interleukin-6 blockade for severe COVID-19 Document date: 2020_4_22
ID: 0ou5f158_6
Snippet: Between March 21 st 2020 and April 2 nd 2020, 30 patients (80% males; median age: 50 years) were treated with tocilizumab, including 7 (23%) in the setting of Intensive Care Unit (ICU) ( Table 1) . After a median (IQR) follow-up of 8 (6.0-9.75) days, and by comparison with a control group of patients (matched for age, gender and disease severity using the inverse probability of treatment weighted methodology with SAS software) (7) that did not re.....
Document: Between March 21 st 2020 and April 2 nd 2020, 30 patients (80% males; median age: 50 years) were treated with tocilizumab, including 7 (23%) in the setting of Intensive Care Unit (ICU) ( Table 1) . After a median (IQR) follow-up of 8 (6.0-9.75) days, and by comparison with a control group of patients (matched for age, gender and disease severity using the inverse probability of treatment weighted methodology with SAS software) (7) that did not receive tocilizumab, IL-6 blockade significantly reduced the requirement of subsequent mechanical ventilation (weighted OR: 0.42; 95%CI[0,20-0,89]; p=0,025).
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