[SOME CYTOGENETIC PARAMETERS IN CHILDREN WITH ACUTE LEUKEMIA ASSOCIATED WITH COVID-19 INFECTION (CASE REPORTS)].

Zedginidze, A; Shengelaia, A; Jashiashvili, S

There are data about 6 cases of acute leukemia in children who have been diagnosed with COVID-19 infection 1-1,5 months before, or at the same time. In 5 patients lymphoblastic and in one monoblastic acute leukemia were diagnosed. The course of leukemia passed without any particular complications. Attention is drawn to the presence in 5 patients of either a clone with high hyperdiploidy, or the presence of an increased number of polyploid cells. At the same time, pulverization and fragmentation of chromosomes often observed during radiation, viral exposure, cancer and precancerous hyperplasia, were found. It is suggested that the mitosis disorder we identified in several cases of COVID-19, accompanied by polyploidy, pulverization and fragmentation of chromosomes, can be regarded as a "second hit " during development of childhood acute leukemia, or as an accelerator of the manifestation of an already existing process.