COVID-19 with and without pneumonia: clinical outcomes in the internal medicine ward.

Melendi, Santiago E; Pérez, María M; Salas, Cintia E; Haedo, Mariana F; Xavier, Franco B; Saltos Navarrete, Jandry D; Aguirre, Camila; Baleta, María L; Balsano, Facundo J; Caldano, Mariano G; Colignon, María G; de Oliveira Brasil, Thayana; de Wolodimeroff, Nicolás; Déramo Aquino, Andrea I; Fernández de Córdova, Ana G; Fontan, María B; Galvagno, Florencia I; Iturrieta Araya, Noelia S; Mollinedo Cruz, Volga S; Olivero, Agustín; Pestalardo, Ignacio; Ricciardi, María; Vera Rueda, María L; Villaverde, María C; Lauko Mauri, Marcela; Ujeda, Carlos; Leis, Rocío

The clinical features of COVID-19 differ substantially upon the presence (or absence) of viral pneumonia. The aim of this article was to describe the clinical characteristics of COVID-19 patients admitted to the Internal Medicine ward, as divided into those with and without pneumonia. This single-center prospective cohort study was conducted in a tertiary teaching public hospital in Buenos Aires City named Hospital General de Agudos Carlos G. Durand. Baseline data collection was performed within 48 hours of admission and patients were followed until discharge or in-hospital death. Epidemiological, clinical, laboratory, and radiological characteristics together with treatment data were obtained from the medical records. Of the 417 included, 243 (58.3%) had pneumonia. Median age was 43 years (IQR:32-57) and 222 (53.2%) were female. The overall crude case-fatality rate was 3.8%. None of the COVID-19 patients without pneumonia developed critical disease, required invasive mechanical ventilation nor died during hospitalization. However, 7 (4%) developed severe disease during follow-up. Among patients with COVID-19 pneumonia, in-hospital mortality rate was 6.6%, severe disease developed in 81 (33.3%), critical disease in 23 (9.5%), and 22 (9.1%) were admitted to the intensive care unit. A largely good prognosis was observed among COVID-19 patients without pneumonia, still, even among this group, unfavorable clinical progression can develop and should be properly monitored. Critical illness among patients with COVID-19 pneumonia was frequent and observed rates from this cohort provide a sound characterization of COVID-19 clinical features in a major city from South America.