Selected article for: "gene expression and microprocessor complex"
Author: Ian M. Silverman; Sager J. Gosai; Nicholas Vrettos; Shawn W. Foley; Nathan D. Berkowitz; Zissimos Mourelatos; Brian D. Gregory
Title: Isolation and sequencing of AGO-bound RNAs reveals characteristics of mammalian stem-loop processing in vivo
  • Document date: 2018_4_6
    • ID: 1pbshnw9_1
    Snippet: MicroRNAs (miRNAs) are ~22 nucleotide (nt) small RNAs (smRNAs) that negatively regulate gene expression at the post-transcriptional level by repressing translation and/or promoting degradation of target messenger RNAs (mRNAs) (1,2). Animal miRNAs are generated in a two-step process, whereby miRNA precursors (pre-miRNAs) are first cleaved from their primary transcripts (pri-miRNAs) by the action of the DGCR8/DROSHA microprocessor complex (3, 4) . .....
    Document: MicroRNAs (miRNAs) are ~22 nucleotide (nt) small RNAs (smRNAs) that negatively regulate gene expression at the post-transcriptional level by repressing translation and/or promoting degradation of target messenger RNAs (mRNAs) (1,2). Animal miRNAs are generated in a two-step process, whereby miRNA precursors (pre-miRNAs) are first cleaved from their primary transcripts (pri-miRNAs) by the action of the DGCR8/DROSHA microprocessor complex (3, 4) . Alternative pre-miRNA biogenesis pathways have been described that bypass the microprocessor. For example, mirtron loci generate pre-miRNAs in a splicing-dependent and DROSHA-independent fashion (5, 6) . Pre-miRNAs are then transported into the cytoplasm by Exportin-5 for further processing (7, 8) .

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