Author: Kenneth N. Hass; Mengdi Bao; Qian He; Myeongkee Park; Peiwu Qin; Ke Du
Title: Integrated Micropillar Polydimethylsiloxane Accurate CRISPR Detection (IMPACT) System for Rapid Viral DNA Sensing Document date: 2020_3_20
ID: d840uu3e_16
Snippet: This IMPACT chip concept can be extended to detect many biomarkers such as exosomes 43 , single cells 44 , and surface proteins 45 . For example, the detection sensitivity of traditional immunoassay approaches is limited due to the low binding capacity. Magnetic beads have been widely used to increase the binding affinity. 46, 47 However, it is difficult to incorporate beads into the microfluidic channel as they easily settle down and get stuck i.....
Document: This IMPACT chip concept can be extended to detect many biomarkers such as exosomes 43 , single cells 44 , and surface proteins 45 . For example, the detection sensitivity of traditional immunoassay approaches is limited due to the low binding capacity. Magnetic beads have been widely used to increase the binding affinity. 46, 47 However, it is difficult to incorporate beads into the microfluidic channel as they easily settle down and get stuck in the channel. In vivo detection is also challenging as the beads emit strong auto-fluorescence. The micropillar arrays that we developed are patterned in the chip and can avoid author/funder. All rights reserved. No reuse allowed without permission.
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