Author: Baldelli, Luca; Amore, Giulia; Montini, Angelica; Panzera, Ivan; Rossi, Simone; Cortelli, Pietro; Guarino, Maria; Rinaldi, Rita; D'Angelo, Roberto
Title: Hyperacute reversible encephalopathy related to cytokine storm following COVID-19 vaccine Cord-id: q4vqmv33 Document date: 2021_9_15
ID: q4vqmv33
Snippet: We describe the first case of hyperacute reversible encephalopathy following COVID-19 vaccination. A patient presented with acute onset encephalopathy, mainly characterized by agitation and confusion, rapidly responsive to high dosage steroid therapy and complete remission within 3 days from onset. The clinical manifestation was related with systemic and CSF cytokine hyperproduction, responsive to steroid therapy. Although the occurrence of encephalopathy after vaccination may be just a casual t
Document: We describe the first case of hyperacute reversible encephalopathy following COVID-19 vaccination. A patient presented with acute onset encephalopathy, mainly characterized by agitation and confusion, rapidly responsive to high dosage steroid therapy and complete remission within 3 days from onset. The clinical manifestation was related with systemic and CSF cytokine hyperproduction, responsive to steroid therapy. Although the occurrence of encephalopathy after vaccination may be just a casual temporal association, we speculate that the cytokine-storm could be the result of an excessive innate immune response against the vaccine, in a predisposed patient susceptible to autoimmunity.
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