Author: Ian M. Silverman; Sager J. Gosai; Nicholas Vrettos; Shawn W. Foley; Nathan D. Berkowitz; Zissimos Mourelatos; Brian D. Gregory
Title: Isolation and sequencing of AGO-bound RNAs reveals characteristics of mammalian stem-loop processing in vivo Document date: 2018_4_6
ID: 1pbshnw9_75
Snippet: Using these unique datasets, we uncovered widespread trimming and non-templated tailing in both pre-and mature miRNAs from human and mouse cells (Figs. 2, S1C-D and S2D-G) . We also identified known and putative ac-pre-miRNAs (Figs. 3A-B and Tables 1 and S3) . The large number of ac-pre-miRNAs identified suggests that DICER-independent pre-miRNA processing may be a more commonly used mechanism than previously appreciated (13, 16, 19) ......
Document: Using these unique datasets, we uncovered widespread trimming and non-templated tailing in both pre-and mature miRNAs from human and mouse cells (Figs. 2, S1C-D and S2D-G) . We also identified known and putative ac-pre-miRNAs (Figs. 3A-B and Tables 1 and S3) . The large number of ac-pre-miRNAs identified suggests that DICER-independent pre-miRNA processing may be a more commonly used mechanism than previously appreciated (13, 16, 19) .
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