Author: Xiang He; Lei Zhang; Qin Ran; Anying Xiong; Junyi Wang; Dehong Wu; Feng Chen; Guoping Li
Title: Integrative Bioinformatics Analysis Provides Insight into the Molecular Mechanisms of 2019-nCoV Document date: 2020_2_5
ID: mjhez5im_19
Snippet: The copyright holder for this preprint . https://doi.org /10.1101 /10. /2020 In order to further analyze the core genes involved in viral replication and inflammatory response mediated by ACE2, we constructed a protein-protein interaction network. It was found that RPS3 played a key role in viral replication, and SRC non-receptor protein kinase was the hub gene in inflammatory response. It has been shown that RPS3 plays an important role in cell .....
Document: The copyright holder for this preprint . https://doi.org /10.1101 /10. /2020 In order to further analyze the core genes involved in viral replication and inflammatory response mediated by ACE2, we constructed a protein-protein interaction network. It was found that RPS3 played a key role in viral replication, and SRC non-receptor protein kinase was the hub gene in inflammatory response. It has been shown that RPS3 plays an important role in cell mitosis by interacting with αtubulin. When cells are infected with HIV-1, HIV-1 Tat protein can interact with RPS3 to disturb its localization on the spindle, and ultimately inhibit cell proliferation (10) .
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