Selected article for: "cell function and NK cell function"
Author: David E. Ochayon; Ayad Ali; Pablo C. Alarcon; Durga Krishnamurthy; Leah C. Kottyan; Michael Borchers; Stephen N. Waggoner
Title: Interleukin-33 promotes type 1 cytokine expression via p38 MAPK in human natural killer cells
  • Document date: 2019_9_20
    • ID: iuhhuy53_20
    Snippet: We augment previous observations in mouse 17, 18 and human 16 NK cells by showing that near-physiological (e.g. pM) concentrations 28, 29 of the type 2 cytokine IL-33 trigger hypersensitivity of primary human NK cells to the type I cytokine IL-12. In addition, superphysiological concentrations of IL-33 and IL-12 synergistically induced the release of TNF and GM-CSF, suggesting that high concentrations of these cytokines in a tissue microenvironme.....
    Document: We augment previous observations in mouse 17, 18 and human 16 NK cells by showing that near-physiological (e.g. pM) concentrations 28, 29 of the type 2 cytokine IL-33 trigger hypersensitivity of primary human NK cells to the type I cytokine IL-12. In addition, superphysiological concentrations of IL-33 and IL-12 synergistically induced the release of TNF and GM-CSF, suggesting that high concentrations of these cytokines in a tissue microenvironment may have even stronger effects on NK-cell function. IL-33-mediated potentiation of IFN- and TNF secretion depended on p38 MAPK, and to a lesser extent, the downstream kinase MK2. Moreover, enhanced TNF secretion was partially attributable to ADAM17. These results highlight the possibility for exaggerated cytokine secretion by human NK cells in physiological setting that are characterized by dual exposure to type 1 (IL-12) and type 2 (IL-33) cytokines.

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